ESM Protein Language Models

The ESM line is maintained at github.com/Biohub/esm (Chan Zuckerberg Biohub, MIT license; the older evolutionaryscale/esm URL redirects here). The current generation ships three artifacts: ESM C (language model), ESMFold2 (structure prediction), and ESM Atlas (a map of predicted structures). Weights are on huggingface.co/biohub; the hosted API is at biohub.ai.

This skill covers ESM C, ESMFold2, and legacy ESM2. ESM3 is not covered because its open weights are non-commercial.

Which model to use