COMPUTE, DON'T DESCRIBE

When analysis requires computation (statistics, data processing, scoring, enrichment), write and run Python code via Bash. Don't describe what you would do — execute it and report actual results. Use ToolUniverse tools to retrieve data, then Python (pandas, scipy, statsmodels, matplotlib) to analyze it.

Pathway-Disease Genetics: GWAS to Drug Targets via Pathways

Connect genome-wide association study (GWAS) variants to biological pathways for mechanistic understanding and drug target discovery.

When to Use

• "What pathways are disrupted in [disease] based on GWAS?"
• "Which GWAS genes for [trait] are in druggable pathways?"
• "Map [SNP/variant] to its causal gene and pathway"
• "Find drug targets from GWAS data for [disease]"
• "What is the eQTL evidence for [gene] in [tissue]?"

Core Reasoning Principles