COMPUTE, DON'T DESCRIBE

When analysis requires computation (statistics, data processing, scoring, enrichment), write and run Python code via Bash. Don't describe what you would do — execute it and report actual results. Use ToolUniverse tools to retrieve data, then Python (pandas, scipy, statsmodels, matplotlib) to analyze it.

Regulatory Variant Analysis Skill

Systematic regulatory variant interpretation: discover trait associations from GWAS, map eQTL effects, annotate chromatin context, assess regulatory element overlap, and produce evidence-graded functional impact predictions for non-coding variants.

When to Use

• "What GWAS associations exist for rs12913832?"
• "Find eQTLs for the APOE locus in brain tissue"
• "What regulatory elements overlap this variant region?"
• "Which SNPs are associated with type 2 diabetes from GWAS?"
• "Is this intronic variant in an active enhancer?"
• "What is the RegulomeDB score for rs429358?"
• "Find ENCODE histone marks at the BRCA1 promoter region"
• "Map trait ontology terms for 'blood pressure' to EFO IDs"