COBRApy - Constraint-Based Reconstruction and Analysis

When to use

Use for loading/building metabolic networks, optimizing their steady-state fluxes, knockout screens, medium design, feasible-space sampling, and gap-filling hypotheses. FBA is a constraint-based prediction; it does not infer kinetic rates or establish experimental growth, thermodynamic feasibility, or flux identifiability.

Setup and reproducibility

Targets cobra 0.32.1 (import cobra), checked against its released source and current documentation.

uv pip install "cobra==0.32.1"
# Optional SciPy support for MATLAB I/O and array operations:
uv pip install "cobra[array]==0.32.1"