DepMap — Cancer Dependency Map

When to use

Use this skill to rank dependencies in cancer models, compare prespecified biomarker cohorts, inspect co-essentiality, or relate genetic dependencies to PRISM compound response. These analyses generate target and synthetic-lethality hypotheses; they do not establish clinical efficacy, a therapeutic window, or a causal interaction.

DepMap integrates Broad and Sanger CRISPR screens and hosts independent RNAi and drug-screen datasets. Match each question to its assay and pinned release. RNAi DEMETER2 is a different perturbation modality, not an older CRISPR scoring method.

1. Discover a release, then obtain its files

Use DepMap Downloads and the selected release's README and release notes. On review, the live catalogue's latest DepMap Public release was 26Q1, dated 2026-04-01. Rediscover before new work; a release name or expected quarter is not evidence a release is available.