ESM: protein generation, embeddings, and folding

When to use

Use for Biohub's esm SDK: ESM3 masked multimodal generation, ESMC sequence representations, and ESMFold2 all-atom prediction. The former Forge platform migrated to https://biohub.ai, including ESM3; SDK class names still contain Forge. This skill targets the released esm 3.4.1.post1, verified against its wheel and current official documentation.

fair-esm is Meta's separate, older ESM2/ESMFold/ESM-IF distribution. Both packages import as esm; install them in separate environments. The legacy esm.pretrained.esm2_* interface is not the Biohub ESMC interface. Hugging Face Transformers' native ESMC implementation is another API: do not interchange its version requirements or output types with this SDK.

Setup and model choice