AlphaGenome and the AlphaGenome Atlas

AlphaGenome is DeepMind's sequence-to-function model: 1 Mb of DNA in, predictions at modality-specific resolutions for eleven assay types across thousands of human and mouse tracks out. The AlphaGenome Atlas (released 2026-09-08) is that model run once over every possible single-nucleotide change in GRCh38, about 9 billion variants, stored with a single ranking number, the AlphaGenome Variant Impact (AVI) score, its genome-wide percentile, and an 18-way attribution of what drives it. Both are reached through one pip install alphagenome and one API key.

Research and theoretical modelling only. API outputs must not be used to train other models, and are not for diagnostic procedures or medical decisions. Permissive-use downloads have separate terms; check the artifact licence.

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