rct-appraisal
RCT Comprehensive Appraisal
Overview
This skill enables systematic, reproducible appraisal of randomized controlled trial (RCT) papers through:
- Multi-framework integration - CONSORT 2025, Cochrane RoB 2.0, GRADE, TIDieR, Benefits/Harms, COI assessment
- Comprehensive bias assessment - Systematic evaluation across 5 risk of bias domains with ~30 signaling questions
- Benefits and harms evaluation - Structured assessment of therapeutic benefits, adverse events, and risk-benefit balance
- Conflicts of interest analysis - Systematic COI detection and impact evaluation
- Evidence certainty grading - GRADE framework for rating confidence in effect estimates
- Dual-validation methodology - Independent concurrent appraisals with concordance analysis
- Editorial writing support - Generate evidence-based 1500-word editorial content on RCT quality
The skill transforms RCT critical appraisal from a subjective, variable process into a systematic, evidence-based workflow (~2-4 hours depending on scope).
When to Use This Skill
Apply this skill when:
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