UniProt Database

UniProt serves as the authoritative resource for protein sequence data and functional annotations. This skill enables programmatic access to search proteins by various criteria, retrieve FASTA sequences, translate identifiers between biological databases, and query both manually curated (Swiss-Prot) and computationally predicted (TrEMBL) protein records.

Use Cases

• Retrieve protein sequences in FASTA format for downstream analysis
• Query proteins by name, gene symbol, organism, or functional terms
• Convert identifiers between UniProt, Ensembl, RefSeq, PDB, and 100+ databases
• Access functional annotations including GO terms, domains, and pathways
• Download curated datasets for machine learning or comparative studies
• Build protein datasets filtered by organism, size, or annotation quality

Installation

No package installation required - UniProt provides a REST API accessed via HTTP requests:

import requests